Scientific News | Researchers discover that a new imaging information system can provide an accurate prognosis for certain cancers

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Washington [US]Sep 17 (ANI): A new imaging information system developed by researchers at the University of Colorado’s Anschutz Medical Campus may possibly provide faster and more accurate prognosis for certain tumors.

Oncologists have long used the Ki67 protein as a biomarker of human tumor cell proliferation. Yet the time, money and method of distribution have challenged medical professionals.

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Fuyong Xing, PhD, first author of the paper and assistant professor in the Department of Biostatistics and Informatics at the Colorado School of Public Health, is the principal investigator of the National Institutes of Health (NIH) R21 project.

The goal is to develop a new imaging information system that automates the process of scanning the Ki67 protein for gastrointestinal and pancreatic neuroendocrine tumors, eventually creating a method for assessing the Ki67 labeling index. which can be shared between medical institutions around the world.

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“The system will significantly improve the efficiency and objectivity of biomarker calculation, so that it can enable rapid disease detection,” Xing said. “This study (cell/nucleus detection) serves as the basis for the evaluation of Ki67 labeling index in our project, and it will provide a low-cost and efficient method for Ki67 scoring in different datasets.”

Currently, oncologists often use “global eye” estimation or manual counting of the number of these cells to determine the prognosis of patients with pancreatic, gastrointestinal and other cancers. The higher the Ki67 protein, the worse the prognosis.

Xing said the study is a key step in developing generalizable algorithms for Ki67 labeling index assessment. It has also been proven that the imaging technology used has a significant improvement in the analysis.

“Compared to current ‘eyeball’ estimation and manual counting approaches for Ki67 assessment in clinical practice, this study has the potential to significantly speed up the procedure for calculating the Ki67 biomarker,” Xing said. . “Furthermore, it would free up pathologists and researchers from daily, routine and tedious work so that they can pay more attention to high-level hypothesis formulation and biological discovery.”

Xing said the imaging computer system could eventually serve as a place where results could be shared and accessed by medical facilities around the world. Currently, there is no universal system for quantifying the labeling index in different datasets, which makes treatment more complicated for patients who are seen at multiple medical facilities.

This part of the study focused on the pancreas[XF1] and gastrointestinal cancers. The indexing and imaging technology will continue to be tested in future studies to determine its long-term viability. (ANI)

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